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中间体  产品名称 CAS 号  结构式  专利号

瑞舒伐他汀钙
 Rosuvastatin methyl ester 147118-40-9   ZL200910053047.3
ZL201511022824.X
ZL201511022872.9
ZL201511023253.1
ZL201510940531.3
 Rosuvastatin tert-butyl ester  355806-00-7  
 Tert-butyl 6-[(1E)-2-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]ethenyl]-2,2-dimethyl-1,3-dioxane-4-acetate 289042-12-2  

阿托伐他汀钙
 4-Fluoro-α-(2-methyl-1-oxopropyl)-γ-oxo-N,β- diphenylbenzene butaneamide 125971-96-2   ZL200810202127.6
 Diprotected Atorvastatin (L1)  125971-95-1  

培哚普利
 N-[(S)-1-Carbethoxybutyl]-(S)-alanine  82834-12-6   ZL201210555176.4
ZL200910266685.3
 (S)-Indoline-2-carboxylic acid 79815-20-6  
 (2S,3aS,7aS)-Octahydro-1H-indole-2-carboxylic acid 80875-98-5  
 (2S,3aS,7aS)-Benzyl octahydro-1H-indole-2-carboxylate 4-methylbenzenesulfonate  94062-52-9  

伊伐布雷定
 3-(3-Iodopropyl)-7,8-dimethoxy-1,3-dihydro-2H-3-benzapine-2-one 148870-57-9  

ZL201010207206.3
ZL201510099954.7
ZL201511018565.3
 

 [N-[[3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl] carbonyl]-N-methylamine] 866783-13-3  
 7,8-Dimethoxy-1,3-dihydro-2H-3-benzazepin-2-one 73942-87-7  

坎地沙坦
Trityl candesartan 139481-72-4   ZL201010229921.7
ZL201510671739.X

加兰他敏
 (+/-) Nawedine 1668-86-6    
4a,5,9,10,11,12-Hexahydro-1-bromo-3-methoxy-11-formyl- 6H-Benzofuro[3a,3,2-ef][2] benzazepine-6-one  122584-14-9  

缬沙坦
 Methyl N-[(2’-Cyanobiphenyl-4-yl)methyl]-L-valinate hydrochloride 482577-59-3   ZL201010173862.6
ZL201510945518.7

氯吡格雷
 (S)-Methyl (2-chlorophenyl)[(2-(2-thienyl)amino] acetate hydrochloride  141109-19-5   ZL201310462551.5

普瑞巴林
 (R)-(-)-3-(Carbamoylmethyl-5-methylmexanoic acid 181289-33-8   ZL201410137925.0
ZL201410675675.6
 3-Carbamoymethyl-5-methylhexanoic acid  181289-15-6  

文拉法辛
 1-[2-Amino-1-(4-methoxyphenyl)-ethyl]-cyclohexanol  130198-05-9   ZL200910100326.0

度洛西汀
 (S)-3-(Methylamino)-1-(2-thienyl)-1-propanol  116539-55-0   ZL201410436429.5
 S-(-)-N,N-Dimethyl-3-hydroxy-3-(2-thienyl)propanamine 132335-44-5  
 S-(+)-N,N-Dimethyl-3-(1-naphthoxy)-3-(2-thienyl)-1-propylamine oxalate 132335-47-8  

阿立哌唑
1-(2,3-Dichlorophenyl)piperazine hydrochloride 119532-26-2    
3,4-Dihydro-7-hydroxy-2(1H)-quinlinone 22246-18-0

达比加群
 Ethyl 3-(4-(methylamino)-3-nitro-N-(pyridin-2-yl)benzamido)propanoate  429659-01-8  

ZL201510411877.4

 3-[(3-Amino-4-methylaminobenzoyl)pyridin-2-ylamino]propionic acid ethyl ester 212322-56-0  
 2-(4-Cyanophenylamino)acetic acid 42288-26-6  
 Ethyl 3-[[[2-[[(4-Cyanophenyl)amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]pyridin-2-ylamino] propionate 211915-84-3  
 N-[[2-[[[4-(Aminoiminomethyl)phenyl]amino]methyl]-1-methyl-1H-benzimidazol-5-yl]carbonyl]-N-2-pyridinyl-beta-alanine ethyl ester  429658-95-7  

维格列汀
 (S)-1-(2-Chloroacetyl)pyrrolidine-2-carboxamide 214398-99-9   ZL201410112710.3
 (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile 207557-35-5  

达格列净
 5-Bromo-2-chloro-4’-ethoxydiphenylmethane 461432-23-5  

ZL201510404207.X

Dapagliflozin base 461432-26-8
(2R,3R,4R,5S)-2-(Acetoxymethyl)-6-(4-chloro-3-(4-ethoxybenzyl)-phenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate 461432-25-7

雷西纳德
 1-Cyclopropyl-4-isothiocyanatonaphthalene 878671-95-5    
 3H-1,2,4-Triazole-3-thione, 5-amino-4-(4-cyclopropyl-1-naphthalenyl)-2,4-dihydro  878671-96-6  
 Isopropyl 2-((5-bromo-4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate  NA  

沙芬酰胺
 4-((3-Fluorobenzyl)oxy)benzaldehyde 66742-57-2   ZL201510952335.8
 (S)-2((4-((3-Fluorobenzyl)oxy)benzyl)amino)propanamide  133865-89-1  

利伐沙班
2-[(2R)-2-hydroxy-3-{[4-(3-oxomorpholin-4-yl)phenyl]amino}propyl]-1H-isoindole-1,3(2H)-dione 446292-07-5   ZL201510952335.8
2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dione 446292-08-6  
4-[4-[(5S)-5-(Aminomethyl)-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone hydrochloride 898543-06-1  

 

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